Alcohol, drugs and mental illness

An addiction to drugs, alcohol and other substances can trigger mental problems. iVillage has linked with the mental health charity SANE to bring you important information

Alcohol and certain drugs can trigger mental health problems, particularly in young people and those who already have mental illness. Many drugs, including those legitimately prescribed to treat other conditions, may interact with the drugs used to treat mental illness, making them less effective and perhaps precipitating a crisis. It is crucial when receiving prescription drugs that you make your doctor aware of your history of mental illness and any psychiatric drugs currently being taken. However, a far greater risk comes from 'street' drugs purchased illegally and without control.

How people become dependent
Three factors seem to be important. The first is the availability of drugs. In the past, many people were introduced to drugs as a result of carelessness and over-prescription by the medical profession. This was true for opiates, barbiturates and, later, amphetamines. Others acquired their addiction from drugs contained in commonly available purchases of the time. For example, many familiar remedies, especially cough medicines, used to be laced with morphine.

The second factor seems to be vulnerability. This is dependent upon the personality of the user and on the setting in which he or she is first introduced to drugs. The third factor is the social pressure exerted by peers who influence or force the young person to abuse drugs to demonstrate status, camaraderie or adulthood.

How drugs are controlled
The supply and use of drugs in the UK are controlled by two Acts of Parliament: the Medicines Act (1968), which governs the manufacture and supply of medicinal products, and the Misuse of Drugs Act (1971), which controls the use of drugs, including those with no medicinal uses. The Misuse of Drugs Act names a number of controlled drugs that are known to be misused, and the Act prohibits their manufacture, supply and possession. It is a criminal offence to contravene this Act and penalties can be high.

The controlled drugs are divided into three categories according to their likely harm from misuse, and penalties vary accordingly. Some of them are especially hazardous for people with mental illness.

Alcohol and drug effects
Hazards of alcohol
Other depressive substances
, including over the counter medicines and solvent abuse
Hormonal drugs
Stimulant substances
, including amphetamines and cocaine
Heroin and methadone
Temazepam, etc.
Hallucinogens
, including LSD, certain mushrooms, ecstasy, GHB and cannabis
What to do if you become addicted

Hazards of alcohol
Alcohol is a particular hazard for people with mental illness because it is readily available and socially acceptable. Initially, it has a stimulating effect and because of this it is frequently taken by those who are depressed. However, after the first feeling of well- being it can increase depression.

Alcoholics can find that alcohol causes personality changes which, as in some mental illnesses, may prevent them having insight into their problem. Loss of recent memory is another common result of over-indulgence in alcohol. It may be so severe that there is no recall of anything that has happened in the immediate past.

The role of alcohol in intensifying depression is well established but it is not yet clear whether it plays any part in triggering schizophrenic illness or causing a relapse. If you are taking drugs prescribed for a mental illness, you should be particularly cautious about alcohol because there may be serious interactions.

Other depressive substances
Apart from alcohol, there are a number of other drugs that have a depressive effect. They include the hypnotics and sedatives (benzodiazepines, barbiturates and others), the tranquillisers (mainly benzodiazepines) and a variety of solvents and gases (the average home contains at least 30 'sniffable' substances).

These substances all behave in a similar way to alcohol, relieving tension, reducing anxiety and decreasing self-control. Frequent use results in tolerance, encouraging you to increase the dose. The barbiturates and some sedatives produce strong dependence, the benzodiazepines less so, and the solvents apparently none.

The depressant effects may be augmented if other depressant drugs are also being taken. People with mental health problems, especially those suffering from depression or taking sedative drugs, should steer clear.

Over-the-counter medicines
A variety of medicines that contain mild mood- altering drugs are available from pharmacies without a doctor's prescription. For example, some cough medicines contain codeine, part of which the body can convert into morphine. Cough and cold remedies also often contain stimulants such as ephedrine. Other cough remedies contain antihistamines, such as promethazine, whose sedative action is increased significantly by alcohol.

Solvent abuse
Solvent abuse (better known as glue-sniffing) is not uncommon because solvents, which are carbon-based substances used in glues, paints, nail varnish removers, aerosols, petrol and cigarette lighter gas, are easily bought over the counter. Solvent vapours are inhaled, passing from the lungs directly to the brain to produce a drunken sensation. The habit seems to be largely confined to secondary school children: surveys show that 7-10 per cent inhale solvents.

A disproportionate number of deaths from solvent abuse are caused by gas fuels (butane) and aerosols rather than glue. Long-term solvent abuse can lead to damage to the brain, kidney and liver. There seems to be no indication that the practice is a cause of schizophrenic relapse. In 1994 alone, 57 deaths in the UK were caused by the inhalation of solvents, adhesives and aerosols; some of the victims were first-time users.

Hormonal drugs
Some medications prescribed for physical conditions can induce psychiatric symptoms. These include steroids, which are used by athletes. In prolonged use or over-dosage, they can produce mood changes of either elation or depression, as well as ideas of persecution. Those with depressive illness should be cautious.

Stimulant substances
The most frequently abused stimulant drugs are amphetamines and cocaine, both of which are illegal. Commonly available drinks such as coffee, tea, cocoa and cola contain the stimulant caffeine, and cigarettes and tobacco contain nicotine. These are all freely available legally and may produce undesirable side effects if taken in excess. These substances stimulate the nervous system, elevate mood, increase alertness and overcome fatigue.

Amphetamines
In the past amphetamines have been used, largely by women, as slimming aids. They are powerful stimulants and increase heart and breathing rate with a feeling of euphoria. They also decrease the appetite so that the anorexic effect in heavy usage may cause serious weight loss and insomnia. Their effect gradually wears off after three or four hours, leaving you anxious, restless and feeling depressed. High doses repeated over several days may result in a so-called 'amphetamine psychosis' in which you feel others are plotting against you and intend you harm.

The drug appears to raise the level of dopamine, one of the neurotransmitters in the brain, in the same way as schizophrenia. It is therefore a bad idea for anyone who has suffered from schizophrenia to take this drug.

Cocaine
Cocaine, a stimulant, produces mental exhilaration, a feeling of well being and an indifference to pain. The drug sometimes causes anxiety or panic and people suffering from anxiety states should be especially careful. Prolonged use of cocaine can lead to severe anxiety and insomnia. In addition, cocaine psychosis can develop, as with amphetamines.

Painkillers
The painkilling opioid drugs not only reduce sensitivity to pain but also allay anxiety and produce feelings of warmth and wellbeing, making them prime targets for misuse. Opiate derivatives such as morphine, heroin and codeine are all highly addictive. This is their main disadvantage and necessitates strict control. Some very dilute solutions and formulations of kaolin and morphine are sold over the counter without restrictions.

The main effects of abuse are the apathy produced by prolonged use, the dangers of overdose (which produces stupor, coma and possibly death from respiratory failure), infection from contaminated needles and the fact that many users turn to crime to finance their habit. Opiate addiction in itself is not a known cause of psychotic breakdown.

Heroin
Heroin is the most sought-after opioid on the street, where it is known as smack, scag, horse, gear and brown, among other names. Heroin is either sniffed, smoked or injected intravenously, the latter producing an almost instantaneous, short-lived rush of euphoria, sometimes accompanied by nausea and vomiting. Inhaling the fumes of heated heroin through a small tube also produces an almost immediate effect but the euphoria lasts longer and is less intense. The opioids are often injected, so you run a high risk of life-threatening infections - especially HIV and hepatitis - if you share needles and syringes.

Methadone
This is an opioid with about the same potency as morphine and similar side effects. Doctors prescribe methadone as a substitute for heroin in people who have become dependent because it is effective by mouth and sufficiently slow acting to be taken once a day. This can help you to regain stability.

Temazepam and similar drugs
The short-acting benzodiazepine drugs, such as temazepam, lorazepam (Ativan) and diazepam (Valium) have fewer side effects than the barbiturates and are less dangerous in overdose. They are, however, associated with withdrawal phenomena that may develop within a few hours of stopping treatment.

Hallucinogens
Hallucinogenic drugs are substances such as LSD and hallucinogenic amphetamines that produce heightened and distorted perceptions, over-activity and, when taken in quantity, can cause a psychotic condition with delusions very similar to those found in schizophrenia.

There is controversy as to whether these drugs can produce a true schizophrenic illness or merely mimic the symptoms. What is clear is that some people diagnosed as having a schizophrenic illness have a history of prolonged indulgence in hallucinogenic drugs. The hallucinogenic psychosis produced may often take a long time to settle and does not necessarily clear up rapidly when the drug is withdrawn. Further indulgence may lead to a relapse and should be avoided.

LSD (Lysergic Acid Diethylamide)
LSD is a drug derived from ergot, a fungus that grows on rye. It is a white powder that is so potent that it is generally mixed with other substances and made into tablets or absorbed on gelatine, paper or sugar cubes. It is taken by mouth, and produces heightened self-awareness, a feeling that colours are stronger, a sensation of being outside one's body and ecstatic or mystical experiences. However, it can also induce severe suicidal depression and potentially dangerous delusions.

LSD may also produce a schizophrenia-like psychosis with paranoia and hallucinations that appear to be much more common among those with actual or incipient mental illness. There is no clear evidence that the use of LSD will trigger schizophrenia or other psychotic illness or bring a relapse, but it would be wise for sufferers not to take the risk.

Hallucinogenic mushrooms
Certain mushrooms contain hallucinogens, such as psilocybin, with properties similar to LSD. It takes about 20-30 Liberty Cap mushrooms, eaten raw, cooked or dried, to produce a hallucinogenic experience. There is a greater physiological effect on heart rate and blood pressure than with LSD, and it is possible that the mushrooms may precipitate a schizophrenic reaction.

Ecstasy
Ecstasy is a hallucinogenic amphetamine that in small doses induces a feeling of euphoria, followed by a sensation of serenity and calm together with a heightened perception of the surroundings. Users often experience a degree of anxiety, panic, confusion and insomnia. Much more rarely, you may experience a paranoid psychosis with hallucinations such as those found with other amphetamines.

About 100,000 people, mostly young, are believed to use Ecstasy each weekend. Most of them have no ill effects, so the drug has gained the reputation of being safe. One of the problems is that it is produced in illicit drug factories and laboratories, so that its composition is very variable and may contain toxic additives or more potent varieties, such as DOB, which is a very strong hallucinogenic amphetamine.

While Ecstasy may initially enhance mood by raising levels of the chemical messenger serotonin in the brain, long-term abuse of the drug may damage serotonin receptors and neurons, causing a depletion of serotonin and mood depression. In addition to the development of psychotic reactions, some deaths have been reported after taking Ecstasy as well as a number of severe reactions, including seizure and prolonged coma, so it is far from being a harmless drug and should not be taken by people with mental illness.

Gamma-Hydroxybutyrate
There are reports from our inner cities of the increasing abuse of the substance GHB, which is used as an anaesthetic in the US and some European countries, although not in the UK. GHB is also available in powder, granule and capsule form and is used as a cheap substitute for such stimulants as amphetamine or Ecstasy. GHB may provoke seizures, respiratory depression and coma.

Cannabis
Cannabis is used as a relaxant and mild intoxicant. Different parts of the plant vary in their potency. Cannabis is by far the most widely used of the street drugs and surveys have shown that at least five per cent of the population admits to having used it. There are about one million users in the UK.

The most common effects are talkativeness, relaxation, cheerfulness and enhanced appreciation of sound and colour. There is a reduction in the ability to do complicated tasks, short-term memory can be affected and there is some difficulty in concentration. Heavy use in some people may produce a similar psychosis to that found in amphetamine users. There is evidence that cannabis can cause temporary psychosis in those who have already experienced schizophrenia. Cannabis is best avoided by any schizophrenia sufferer since it may aggravate the condition.

How pure are street drugs?
Drugs bought on the street will either have been medical drugs stolen from the manufacturer at some point in the distribution chain, or will have been imported or manufactured illicitly. Many of these drugs will be impure and may have been adulterated. For this reason, the strength of the drug preparation is unknown (or there may in fact be no active agent present at all) and the adulterants may be very dangerous, especially if injected.

What to do if you become addicted
Although some people who have become dependent on drugs can break from them by their own initiative, most find it difficult. Help is available through your family doctor or through specialist agencies. Such assistance is designed to combine withdrawal from the drug with psychotherapeutic insights into the reasons why you need to escape through the use of drugs.